=SUM(A:B) would add up all the cells in both column A and B.
Cute, but is it useful? Yes, in a worksheet of email addresses I use for one of my emailings, I need to know how many are on the list. At the top of the worksheet I created a formula containing =COUNTA(A:A)-1 to count the number of emails in the list. I subtracted 1 to exclude counting the row containing the column heading.